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Evidence based medicine is at the core of modern medicine. It involves the integration of individual clinical expertise with the best available clinical evidence from systematic research and patient's values and expectations. Systematic reviews offer a summary of the best available evidence. They are the most reliable and comprehensive statement about what works. Written by clinical academics from Australia, UK, USA, and Switzerland, this contributed volume introduces the readers to the principles and practice of systematic reviews and meta-analysis. It covers the various steps involved in systematic reviews including development of a focused question and the strategy for conducting a comprehensive literature search, identifying studies addressing the underlying question, assessment of heterogeneity and the risk of bias in the included studies, data extraction, and the approach to meta-analysis. Crucial issues such as selecting the model for meta-analysis, generating and interpreting forest plots, assessing the risk of publication bias, cautions in the interpretation of subgroup and sensitivity analyses, rating certainty of the evidence using GRADE guideline, and standardized reporting of meta-analysis (PRISMA) are covered in detail. Every attempt is made to keep the narrative simple and clear. Mathematical formulae are avoided as much as possible. While the focus of this book is on systematic reviews and meta-analyses of randomised controlled trials (RCTs), the gold standard of clinical research, the essentials of systematic reviews of non-RCTs, diagnostic test accuracy studies, animal studies, individual participant data meta-analysis, and network meta-analysis are also covered. Readers from all faculties of medicine will enjoy this comprehensive and reader friendly book to understand the principles and practice of systematic reviews and meta-analysis for guiding their clinical practice and research.
Systematic reviews (Medical research) --- Reviews, Systematic (Medical research) --- Medicine --- Evidence-based medicine --- Research --- Ressenyes sistemàtiques (Investigació mèdica) --- Metaanàlisi --- Psicometria --- Revisions sistemàtiques (Investigació mèdica) --- Investigació mèdica --- Medicina basada en l'evidència
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This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues. The key topics address contagious diseases, in particular the epidemiology, clinical presentation, and management of influenza and influenza-like infections as well as brain tuberculosis. Pulmonary medicine is represented by articles addressing a range of practical issues, including the diagnosis, symptoms, comorbidities, and treatment of obstructive sleep apnea, a syndrome whose incidence shows a persistent upward trend worldwide. Other articles address the pathogenesis of air pollution toxicity and allergy and sensory irritation in toxic exposure studies. An intriguing relation of atopic dermatitis to depression and serotoninergic system is debated. The book attempts to integrate research into clinical work and to implement findings to improve care and to decrease suffering from diseases. It is dedicated to the practicing professionals, researchers, and all engaged in health care.
Medicine, Research. --- Human physiology. --- Physiology. --- Epidemiology. --- Human Physiology. --- Diseases --- Public health --- Animal physiology --- Animals --- Biology --- Anatomy --- Human biology --- Medical sciences --- Physiology --- Human body --- Investigació mèdica --- Epidemiologia --- Salut pública --- Comorbiditat --- Epidèmies --- Epidemiologia molecular --- Farmacoepidemiologia --- Morbiditat --- Malalties --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori
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Medicine --- Medical writing. --- Research. --- Hygiene --- Medical sciences --- Public health --- Technical writing --- Health Workforce --- Authorship --- Investigació mèdica --- Literatura científica --- Documentació científica --- Escrits científics --- Publicacions científiques --- Informes tècnics --- Investigació --- Investigació biomèdica --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori
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Nervous system --- Radiography. --- Neuroradiography --- Neuroradiology --- Diseases --- Sistema nerviós --- Oncologia --- Medicina basada en l'evidència --- EBM --- MBE --- Medicina clínica --- Infermeria basada en l'evidència --- Ressenyes sistemàtiques (Investigació mèdica) --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Tumors --- Anatomia --- Ment i cos --- Circuit neuronal --- Examen neurològic --- Nervis --- Sistema nerviós autònom --- Sistema nerviós central --- Sistemes de control biològic --- Teixit nerviós --- Neurociències
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Neurosciences --- Research. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Neurociències --- Investigació mèdica --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Neurociència --- Ciències neurològiques --- Ciències de la salut --- Neuroanatomia --- Neurobiologia --- Neurociència computacional --- Neuroendocrinologia --- Neurofarmacologia --- Neurogenètica --- Neuroquímica --- Sistema nerviós
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This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.
Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Lesions cerebrals --- Assaigs clínics --- Investigació mèdica --- Manuals de laboratori --- Tècniques de laboratori --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Assaigs terapèutics --- Estudis clínics --- Estudis terapèutics --- Dany cerebral --- Danys cerebrals --- Disfuncions cerebrals --- Lesió cerebral --- Malalties cerebrals --- Psicopatologia --- Encefalopatia hepàtica --- Estat vegetatiu persistent --- Paràlisi cerebral --- Pacients amb lesions cerebrals
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This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
Cancer research. --- Medical microbiology. --- Cell biology. --- Pediatrics. --- Cancer Research. --- Medical Microbiology. --- Cell Biology. --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer research --- Diseases --- Health and hygiene --- Cancer --- Research. --- Osteosarcoma --- Sarcoma --- Investigació mèdica --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Sarcomes --- Tumors del teixit connectiu --- Càncer --- Tumors --- Sarcoma osteogen --- Sarcoma osteoide --- Càncer d'ossos --- Sarcoma d'Ewing
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The systematic review is a rigorous method of collating and synthesizing evidence from multiple studies, producing a whole greater than the sum of parts. This textbook is an authoritative and accessible guide to an activity that is often found overwhelming. The authors steer readers on a logical, sequential path through the process, taking account of the different needs of researchers, students and practitioners. Practical guidance is provided on the fundamentals of systematic reviewing and also on advanced techniques such as meta-analysis. Examples are given in each chapter, with a succinct glossary to support the text. This up-to-date, accessible textbook will satisfy the needs of students, practitioners and educators in the sphere of healthcare, and contribute to improving the quality of evidence-based practice. The authors will advise some freely available or inexpensive open source/access resources (such as PubMed, R and Zotero) to help students how to perform a systemic review, in particular those with limited resources. .
Nursing—Research. --- Nursing—Study and teaching. --- Study skills. --- Nursing Research. --- Nursing Education. --- Research Skills. --- How to study --- Learning, Art of --- Method of study --- Study, Method of --- Study methods --- Life skills --- Literatura científica --- Investigació mèdica --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Documentació científica --- Escrits científics --- Publicacions científiques --- Informes tècnics --- Nursing --- Medicine --- Research. --- Study and teaching. --- Health Workforce --- Nursing education --- Medical education --- Nursing research --- Research --- Methodology.
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Headache --- Treatment. --- therapy. --- Cefalàlgia --- Terapèutica --- Medicina basada en l'evidència --- EBM --- MBE --- Medicina clínica --- Infermeria basada en l'evidència --- Ressenyes sistemàtiques (Investigació mèdica) --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Quimioteràpia --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Mal de cap --- Cefalea --- Dolor --- Migranya
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The systematic review is a rigorous method of collating and synthesizing evidence from multiple studies, producing a whole greater than the sum of parts. This textbook is an authoritative and accessible guide to an activity that is often found overwhelming. The authors steer readers on a logical, sequential path through the process, taking account of the different needs of researchers, students and practitioners. Practical guidance is provided on the fundamentals of systematic reviewing and also on advanced techniques such as meta-analysis. Examples are given in each chapter, with a succinct glossary to support the text. This up-to-date, accessible textbook will satisfy the needs of students, practitioners and educators in the sphere of healthcare, and contribute to improving the quality of evidence-based practice. The authors will advise some freely available or inexpensive open source/access resources (such as PubMed, R and Zotero) to help students how to perform a systemic review, in particular those with limited resources. .
Science --- Study methods --- Higher education --- Nursing --- HO (hoger onderwijs) --- verpleegkundig onderzoek --- verpleegkunde --- studievaardigheden --- Medicine --- Study skills. --- Nursing Research. --- Nursing Education. --- Research Skills. --- Literatura científica --- Investigació mèdica --- Research. --- Study and teaching. --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Documentació científica --- Escrits científics --- Publicacions científiques --- Informes tècnics --- How to study --- Learning, Art of --- Method of study --- Study, Method of --- Life skills --- Health Workforce --- Nursing education --- Medical education --- Nursing research --- Systematic reviews (Medical research) --- Revues systématiques
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